The Difficulty Detecting Tuberculosis in a Child with Post-COVID-19 and Cerebral Palsy.
Andjelka StojkovicIrena M IlicAndrijana KosticKaterina DajicZorica RaskovicJelena NestorovicMilena D IlicPublished in: Diagnostics (Basel, Switzerland) (2023)
When hypostatic pneumonia is present at the same time as COVID-19 pneumonia, the clinical course is almost always prolonged (prolonged-COVID-19) due to persistent inflammation, long-term anti-inflammatory syndrome, followed by immune exhaustion, i.e., by immunosuppression and catabolic syndrome. In the immunosuppression phase, viral reactivation can be accompanied by a secondary infection, which, in this case, is pulmonary tuberculosis. Pulmonary tuberculosis in post-COVID-19 patients and in patients with spastic quadriplegic cerebral palsy does not have a typical clinical course nor laboratory, radiological, immunological, microbiological, or fiberbronchoscopic pathohistological confirmation. Due to this, the treatment of pulmonary tuberculosis was not carried out on time, postponed after the unsuccessful treatment of sepsis, post-COVID-19, and other accompanying viral (adenovirus, RSV) and bacterial (streptococcus viridans) infections. The treatment of pulmonary tuberculosis was possible only "ex juvantibus" (trial) post-COVID-19. It becomes imperative to search for a new, more precise and reliable diagnostic test for the detection of tuberculosis bacillus.
Keyphrases
- pulmonary tuberculosis
- sars cov
- mycobacterium tuberculosis
- cerebral palsy
- coronavirus disease
- respiratory syndrome coronavirus
- clinical trial
- acute kidney injury
- randomized controlled trial
- mental health
- anti inflammatory
- oxidative stress
- emergency department
- study protocol
- staphylococcus aureus
- case report
- escherichia coli
- cystic fibrosis
- replacement therapy
- combination therapy
- hiv infected
- smoking cessation
- gene therapy