Plasma Immune Biomarkers Predictive of Progression to Active Tuberculosis in Household Contacts of TB Patients.
Anuradha RajamanickamEvangeline Ann DanielBindu DasanKannan ThiruvengadamPadmapriyadarsini ChandrasekaranSanjay GaikwadSathyamurthi PattabiramanBrindha BhanuAmsaveni SivaprakasamVandana KulkarniRajesh KaryakarteMandar ParadkarShri Vijay Bala Yogendra ShivakumarVidya MaveAmita GuptaLuke Elizabeth HannaSubash BabuPublished in: The Journal of infectious diseases (2024)
Our study suggests that a specific set of plasma biomarkers GM-CSF, CXCL10 and IL-1Ra, can effectively identify household contacts at significant risk of developing TB disease. These findings have important implications for early intervention and preventive strategies in TB-endemic regions.
Keyphrases
- mycobacterium tuberculosis
- end stage renal disease
- randomized controlled trial
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- emergency department
- pulmonary tuberculosis
- patient reported outcomes
- hiv aids
- ankylosing spondylitis
- hepatitis c virus
- cerebrospinal fluid
- human immunodeficiency virus
- antiretroviral therapy
- adverse drug
- systemic sclerosis