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Extracellular Matrix Injury of Kidney Allografts in Antibody-Mediated Rejection: A Proteomics Study.

Sergi Clotet-FreixasCaitríona M McEvoyIhor BatruchChiara PastrelloMax KotlyarJulie Anh Dung VanMadhurangi ArambewelaAlex BoshartSofia FarkonaYun NiuYanhong LiOlusegun FamureAndrea BozovicVathany KulasingamPeixuen ChenS Joseph KimEmilie ChanSajad MoshkelgoshaSyed Ashiqur RahmanJishnu DasTereza MartinuStephen JuvetIgor JurisicaAndrzej ChruscinskiRohan JohnAna Konvalinka
Published in: Journal of the American Society of Nephrology : JASN (2020)
Basement membranes are often remodeled in chronic AMR. Proteomic analysis performed on laser-captured and microdissected glomeruli and tubulointerstitium identified early ECM remodeling, which may represent a new therapeutic opportunity.
Keyphrases
  • extracellular matrix
  • mass spectrometry