Extracellular Matrix Injury of Kidney Allografts in Antibody-Mediated Rejection: A Proteomics Study.
Sergi Clotet-FreixasCaitríona M McEvoyIhor BatruchChiara PastrelloMax KotlyarJulie Anh Dung VanMadhurangi ArambewelaAlex BoshartSofia FarkonaYun NiuYanhong LiOlusegun FamureAndrea BozovicVathany KulasingamPeixuen ChenS Joseph KimEmilie ChanSajad MoshkelgoshaSyed Ashiqur RahmanJishnu DasTereza MartinuStephen JuvetIgor JurisicaAndrzej ChruscinskiRohan JohnAna KonvalinkaPublished in: Journal of the American Society of Nephrology : JASN (2020)
Basement membranes are often remodeled in chronic AMR. Proteomic analysis performed on laser-captured and microdissected glomeruli and tubulointerstitium identified early ECM remodeling, which may represent a new therapeutic opportunity.
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