Whole-genome sequencing predicting phenotypic antitubercular drug resistance: meta-analysis.

Yoichi TagamiNobuyuki HoritaMegumi KanekoSuguru MuraokaNobuhiko FukudaAmi IzawaAyami KanekoKohei SomekawaChisato KamimakiHiromi MatsumotoKatsushi TanakaKota MurohashiAyako AokiHiroaki FujiiKeisuke WatanabeYu HaraNobuaki KobayashiTakeshi Kaneko

Published in: The Journal of infectious diseases (2023)

WGS accurately identifies isoniazid and rifampicin resistance. For most drugs, positive WGS results reliably predict pDST positive. The two approaches had similar ability.

Keyphrases

mycobacterium tuberculosis
systematic review
meta analyses
genome wide
pulmonary tuberculosis
randomized controlled trial
gene expression