MiR-7-5p-mediated downregulation of PARP1 impacts DNA homologous recombination repair and resistance to doxorubicin in small cell lung cancer.
Jinzhi LaiHainan YangYanyang ZhuMei RuanYayu HuangQiuyu ZhangPublished in: BMC cancer (2019)
Our findings provide evidence that miR-7-5p targets PARP1 to exert its suppressive effects on HR repair, indicating that the alteration of the expression of miR-7-5p may be a promising strategy for overcoming chemo-resistance in SCLC therapy.
Keyphrases
- squamous cell carcinoma
- dna repair
- dna damage
- small cell lung cancer
- poor prognosis
- cancer therapy
- photodynamic therapy
- circulating tumor
- cell proliferation
- oxidative stress
- drug delivery
- signaling pathway
- single molecule
- cell free
- binding protein
- long non coding rna
- radiation therapy
- stem cells
- bone marrow
- nucleic acid
- cell therapy
- smoking cessation