Login / Signup

Systematic review of genetic variants associated with cognitive impairment and depressive symptoms in Parkinson's disease.

Tyrra D'SouzaAnto P Rajkumar
Published in: Acta neuropsychiatrica (2019)
PD carriers of GBA variants are at high risk for cognitive decline and depression. Screening for these variants may facilitate early identification and effective management of these non-motor symptoms. The molecular mechanisms underlying favourable cognitive functioning in LRRK2 rs34637584 variant carriers warrant further investigation.
Keyphrases
  • cognitive decline
  • depressive symptoms
  • systematic review
  • cognitive impairment
  • mild cognitive impairment
  • sleep quality
  • copy number
  • meta analyses
  • social support
  • single molecule
  • gene expression