Macrophage OTUD1-CARD9 axis drives isoproterenol-induced inflammatory heart remodelling.

Jinfu QianQinyan WangJiachen XuShiqi LiangQingsong ZhengXiaocheng GuoWu LuoWeijian HuangXiaohong LongJulian MinYi WangGaojun WuGuang Liang

Published in: Clinical and translational medicine (2024)

Macrophage CARD9 was elevated in heart tissues of mice under chronic ISO administration. Either whole-body CARD9 knockout or myeloid-specific CARD9 deficiency protected mice from ISO-induced inflammatory heart remodeling. ISO promoted the assembly of CBM complex and then activated NF-κB signaling in macrophages through OTUD1-mediated deubiquitinating modification. OTUD1 deletion in myeloid cells protected hearts from ISO-induced injuries in mice.

Keyphrases

high glucose
diabetic rats
oxidative stress
heart failure
high fat diet induced
drug induced
adipose tissue
acute myeloid leukemia
atrial fibrillation
induced apoptosis
gene expression
signaling pathway
endothelial cells
metabolic syndrome
cell proliferation
inflammatory response
toll like receptor