Targeting genotoxic and proteotoxic stress-response pathways in human prostate cancer by clinically available PARP inhibitors, vorinostat and disulfiram.

Dusana MajeraZdenek SkrottJan BouchalJirina BartkovaDana SimkovaMariam GachechiladzeJana SteigerovaDaniela KurfurstovaJan GurskyGabriela KorinkovaKarel CwiertkaZdenek HodnyMartin MistrikJiri Bartek

Published in: The Prostate (2018)

We propose that targeting genotoxic and proteotoxic stress responses by combinations of available drugs could inspire innovative strategies to treat castration-resistant PCa.

Keyphrases

prostate cancer
endothelial cells
radical prostatectomy
dna damage
pluripotent stem cells
histone deacetylase
drug induced