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Novel pentafluorosulfanyl-containing triclocarban analogs selectively kill Gram-positive bacteria.

Ali PormohammadMelika MoradiJosefien W HommesEugènia PujolLieve NaesensSantiago VázquezBas G J SurewaardMohammad ZareiManuel Vazquez-CarreraRaymond Joseph Turner
Published in: Microbiology spectrum (2024)
. What sets these novel analogs apart is their superior efficacy at substantially lower concentrations compared with commonly used antibiotics like ciprofloxacin and gentamycin. Importantly, these compounds act by disrupting the bacterial cell membrane, offering a unique mechanism that could potentially circumvent existing resistance mechanisms. Preliminary safety assessments also highlight their potential for therapeutic use. This study not only opens new avenues for combating antibiotic-resistant infections but also underscores the importance of innovative chemical approaches in addressing the global antimicrobial resistance crisis.
Keyphrases
  • antimicrobial resistance
  • molecular docking
  • pseudomonas aeruginosa
  • gram negative
  • human health
  • climate change