MAFA and MAFB regulate exocytosis-related genes in human β-cells.
Luis Rodrigo CataldoTania SinghKavya AchantaSara BsharatRashmi B PrasadCheng LuanErik RenströmLena EliassonIsabella ArtnerPublished in: Acta physiologica (Oxford, England) (2022)
Our data indicate that STXBP1 and STX1A are important MAFA/B-regulated exocytosis genes which may contribute to insulin exocytosis defects observed in MAFA-deficient human T2D β cells.
Keyphrases
- induced apoptosis
- endothelial cells
- type diabetes
- cell cycle arrest
- genome wide
- electronic health record
- induced pluripotent stem cells
- pluripotent stem cells
- endoplasmic reticulum stress
- big data
- signaling pathway
- gene expression
- adipose tissue
- glycemic control
- oxidative stress
- bioinformatics analysis
- dna methylation
- skeletal muscle
- metabolic syndrome
- data analysis