A Bioinformatics Tool for Identifying Intratumoral Microbes from the ORIEN Dataset.
Cankun WangAnjun MaYingjie LiMegan E McNuttShiqi ZhangJiangjiang ZhuRebecca HoydCaroline E DravillasLary A RobinsonCarlos H F ChanYousef ZakhariaRebecca D DoddCornelia M UlrichSheetal HardikarMichelle L ChurchmanAhmad A TarhiniEric A SingerAlexandra P IkeguchiMartin D McCarterNicholas C DenkoGabriel TinocoMarium HusainNing JinAfaf E G OsmanIslam El JilanyAik Choon TanSamuel S ColemanLouis DenkoGregory M RiedlingerBryan Paul SchneiderDaniel J SpakowiczQin Manull nullPublished in: Cancer research communications (2024)
Studying the tumor microbiome in high-throughput sequencing data is challenging because of the extremely sparse data matrices, heterogeneity, and high likelihood of contamination. We present a new deep learning tool, MEGA, to refine the organisms that interact with tumors.