Evaluation of Beta-Catenin Subcellular Localization and Water Channel Protein AQP1 Expression as Predictive Markers of Chemo-Resistance in Ovarian High-Grade Serous Carcinoma: Comparative Study between Preoperative Peritoneal Biopsies and Surgical Samples.
Giuseppe AngelicoAntonio IeniRosario CaltabianoAngela SantoroFrediano InzaniSaveria SpadolaGiovanni TuccariAntonio MacrìGian Franco ZannoniPublished in: Diagnostics (Basel, Switzerland) (2021)
Our findings suggest that β-catenin and AQP1 are expressed in a sub-group of ovarian tumors and play important roles in carcinogenesis. Patients affected by high grade serous carcinoma could be categorized in two different predictive groups: as AQP+ and AQP-. AQP+ cases may represent a subset of poor responders who could be considered more eligible for cytoreductive surgery rather than for neoadjuvant chemotherapy.
Keyphrases
- high grade
- neoadjuvant chemotherapy
- low grade
- locally advanced
- end stage renal disease
- epithelial mesenchymal transition
- newly diagnosed
- lymph node
- poor prognosis
- cell proliferation
- ejection fraction
- minimally invasive
- patients undergoing
- chronic kidney disease
- binding protein
- photodynamic therapy
- squamous cell carcinoma
- rectal cancer
- protein protein
- coronary artery bypass
- signaling pathway
- percutaneous coronary intervention
- coronary artery disease
- patient reported
- amino acid
- ultrasound guided
- atrial fibrillation