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Neoadjuvant Approaches in Hepatocellular Carcinoma: There's No Time Like the Present.

Joseph W FransesAndrew X Zhu
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Hepatocellular carcinoma (HCC) remains a lethal malignancy and is an increasingly common cause of cancer death worldwide. Curative-intent surgical resection remains the standard of care for eligible patients, yet outcomes remain poor for many patients, with most patients experiencing recurrence in the 5 years after resection. There is currently significant interest in using locoregional and systemic therapies-in both the neoadjuvant and adjuvant settings-to increase the chance of cure. This review article appraises the existing literature and current clinical trial landscape of neoadjuvant therapies in HCC.
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