The association between serum uric acid and cognitive function among middle-aged and older adults without hyperuricemia: The mediating role of depressive symptoms.

Higher baseline SUA level is associated with better baseline cognition and less subsequent cognitive decline among Chinese adults without hyperuricemia. Baseline depressive symptoms may partially mediate the association between baseline SUA and later cognition. Continued research is warranted to verify these findings and elucidate the causality and underlying mechanisms.