Copy number variation is highly correlated with differential gene expression: a pan-cancer study.
Xin ShaoNing LvJie LiaoJinbo LongRui XueNi AiDonghang XuXiaohui FanPublished in: BMC medical genetics (2019)
This study shows the close correlation between CNV and differential gene expression revealing the qualitative relationship between genetic variation and its downstream effect, especially for oncogenes and tumor suppressor genes. It is of a critical importance to elucidate the relationship between copy number variation and gene expression for prevention, diagnosis and treatment of cancer.