Susceptibility loci for sporadic brain arteriovenous malformation; a replication study and meta-analysis.

P H C KremerB P C KoelemanGabriël J E RinkelF P DiekstraL H van den BergJ H VeldinkC J M Klijn

Published in: Journal of neurology, neurosurgery, and psychiatry (2015)

The results of this study support a role for the previously identified SNP near ANGPTL4 in the pathogenesis of AVMs. Previously found associations with SNPs near IL-1β, GPR124, VEGFA and MMP-3 genes could not be substantiated in our replication cohort or in the meta-analysis.

Keyphrases

genome wide
systematic review
gene expression
dna methylation
fatty acid
resting state
transcription factor
subarachnoid hemorrhage
early onset
brain injury
meta analyses
genome wide identification
bioinformatics analysis