Transcriptomic Profiling of Peripheral B Cells in Antibody Positive Sjogren's Patients Reveals Interferon Signature.
Mehrnaz Maleki-FischbachKelsey AndersonEvans R Fernández PérezPublished in: Genes (2024)
We found upregulated expression of type-I and type-II interferon (IFN)-induced genes, as well as genes that may contribute to other concomitant conditions, including infections and a higher risk of myeloproliferative disorders. This adds insight into the autoimmune process and suggests potential targets for future functional and prognostic studies.
Keyphrases
- dendritic cells
- end stage renal disease
- genome wide
- chronic kidney disease
- ejection fraction
- single cell
- newly diagnosed
- poor prognosis
- immune response
- multiple sclerosis
- drug induced
- diabetic rats
- gene expression
- dna methylation
- rna seq
- high glucose
- long non coding rna
- oxidative stress
- binding protein
- human health
- stress induced