Knockout of apolipoprotein A-I decreases parenchymal and vascular β-amyloid pathology in the Tg2576 mouse model of Alzheimer's disease.

Published in: Neuropathology and applied neurobiology (2019)

These data suggest that deletion of apoA-I is associated with increased clearance of Aβ and reduced parenchymal and vascular Aβ pathology in the Tg2576 model. These results suggest that peripheral dyslipidaemia can modulate the expression of apolipoproteins in the brain and may influence Aβ clearance and aggregation in AD.

Keyphrases

mouse model
poor prognosis
electronic health record
cognitive decline
white matter
big data
long non coding rna
multiple sclerosis
cerebral ischemia
data analysis
blood brain barrier