Disrupted mitochondrial response to nutrients is a presymptomatic event in the cortex of the APP SAA knock-in mouse model of Alzheimer's disease.
Andrés NorambuenaVijay Kumar SagarZhuoying WangPrakash RautZiang FengHorst WallrabeEvelyn PardoTaylor KimShagufta Rehman AlamSong HuAmmasi PeriasamyGeorge S BloomPublished in: bioRxiv : the preprint server for biology (2024)
mice, and may represent an early stage in human AD.
Keyphrases
- early stage
- mouse model
- endothelial cells
- functional connectivity
- oxidative stress
- resting state
- induced pluripotent stem cells
- cognitive decline
- heavy metals
- high fat diet induced
- pluripotent stem cells
- sentinel lymph node
- squamous cell carcinoma
- adipose tissue
- radiation therapy
- lymph node
- metabolic syndrome
- mild cognitive impairment
- insulin resistance