Orthologous proteins of experimental de- and remyelination are differentially regulated in the CSF proteome of multiple sclerosis subtypes.
Nellie A MartinArkadiusz NawrockiViktor MolnarMaria L ElkjaerEva K ThygesenMiklos PalkovitsPeter AcsTobias SejbaekHelle H NielsenZoltan HegedusFinn SellebjergTihamer MolnarEudes G V BarbosaNicolas AlcarazFerenc GallyasAsa F SvenningsenJan BaumbachHans LassmannMartin R LarsenZsolt IllesPublished in: PloS one (2018)
Pathology-based multi-omics identified four CSF markers that were differentially expressed in MS subtypes. Upregulated TIMP-1, UFO and B2M orthologues in relapsing MS were associated with reduced inflammation and reflected reparatory processes, in contrast to the upregulated orthologue APOC2 in progressive MS that reflected changes in lipid metabolism associated with increased inflammation.