Pharmacokinetic and pharmacogenetic associations with dolutegravir neuropsychiatric adverse events in an African population.
Rulan GrieselPhumla SinxadiAida KawumaJohn JoskaSimiso Mandisa SokhelaGodspower AkpomiemieWillem Daniel Francois VenterPaolo DentiDavid W HaasGary MaartensPublished in: The Journal of antimicrobial chemotherapy (2022)
Only at week 12 did we find evidence of a relationship between dolutegravir exposure and worsening sleep quality. However, higher dolutegravir exposure was associated with improved MMS scores, suggesting a possible beneficial effect.