Knockdown of programmed cell death factor 4 restores erectile function by attenuating apoptosis in rats with bilateral cavernous nerve crush injury.

Yunlong GeTian XiaZejia FengYuhang XiDaoyuan HuYude HongBowen TangJianjie WuJialiang ChenHengjun Xiao

Published in: Andrology (2024)

Elevated programmed cell death factor 4 expression may be an important pathogenetic mechanism for erectile dysfunction after bilateral cavernous nerve crush, and the knockdown of programmed cell death factor 4 enhanced erectile function in 18-month-old rats after cavernous nerve damage. The potential mechanism may be the stimulation of the PI3K/AKT pathway to attenuate the cavernous apoptosis level.

Keyphrases

oxidative stress
endoplasmic reticulum stress
peripheral nerve
cell cycle arrest
cell death
poor prognosis
case report
optic nerve
climate change
binding protein