Exploring miRNA Profiles in Colon Cancer: A Focus on miR101-3p, miR106a-5p, and miR326.
Constantin-Dan TâlvanElena-Teodora TâlvanCălin Ilie MohorLiviuta BudisanValentin GrecuManuela MihalacheOana ZănoagăSergiu ChiraIoana Berindan NeagoeVictor CristeaCosmin Ioan MohorPublished in: Cancers (2024)
Early diagnosis and prognosis of cancer progression through biomarker profiling are crucial in managing colon cancer patients. Our research aimed to investigate the expression of miR-101-3p, miR-106a-5p, and miR-326 in tumor and adjacent healthy tissues of colon cancer patients and determine their potential diagnostic utility. This study included 40 patients divided into four groups according to the TNM staging classification. MiRNA expression was analyzed using qRT-PCR. The results showed that miR-101-3p, miR-106a-5p, and miR-326 are overexpressed in adjacent healthy tissues but decrease in advanced cancer stages. MiR-106a-5p and miR-326 are strongly correlated with colon cancer severity. These findings suggest that miRNA profiling could be useful for early diagnosis and prognosis in colon cancer management.
Keyphrases
- cell proliferation
- long non coding rna
- end stage renal disease
- poor prognosis
- long noncoding rna
- ejection fraction
- newly diagnosed
- chronic kidney disease
- gene expression
- machine learning
- palliative care
- lymph node
- prognostic factors
- patient reported outcomes
- squamous cell carcinoma
- deep learning
- single cell
- risk assessment
- young adults
- climate change
- human health