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Mild, Fast, and Easy To Conduct MoCl5-Mediated Dehydrogenative Coupling Reactions in Flow.

Sebastian B BeilIse UeckerPeter FranzmannTimo MüllerSiegfried R Waldvogel
Published in: Organic letters (2018)
A convenient and straightforward approach to performing oxidative coupling reactions in flow is presented. A collection of electron-rich benzene derivatives was subjected to this protocol, and the distinct utility of molybdenum pentachloride (MoCl5) is established. Using this unexplored protocol, biphenyls could be obtained in 21-91% isolated yield. This simple protocol opens a new chapter in reagent-mediated dehydrogenative coupling reactions, and yields are compared to classical approaches.
Keyphrases
  • randomized controlled trial
  • room temperature
  • electron transfer