Mitigated suppressive function of regulatory T cells (Treg) upon Th17-inducing cytokines in oligo- and polyarticular Juvenile Idiopathic Arthritis (JIA) patients.

Marie-Therese HolzerGiovanni AlmanzarRobert WoidichBoris HügleJohannes-Peter HaasMartina Prelog

Published in: Pediatric rheumatology online journal (2022)

Our results demonstrate an induction of FoxP3 expressing Treg by Th17-inducing cytokines with concomitant mitigated suppressive function. In contrast, specific IL-17A blockade maintains suppressive Treg function and adjusted FoxP3-expression in JIA to levels found in controls. These findings may help to provide experimental evidence for the successful clinical use of IL-17A inhibition in JIA patients.

Keyphrases

juvenile idiopathic arthritis
regulatory t cells
end stage renal disease
ejection fraction
chronic kidney disease
prognostic factors
magnetic resonance
poor prognosis
dendritic cells
disease activity
magnetic resonance imaging
immune response
computed tomography
patient reported outcomes
contrast enhanced