Loss of p73 Expression Contributes to Chronic Obstructive Pulmonary Disease.
Bradley W RichmondClayton B MarshallJessica B BlackburnTiffany S TufenkjianBrian D LehmannWei HanDawn NewcombSergey S GutorRaphael P HuntDanielle L MichellKasey C VickersVasiliy V PolosukhinTimothy S BlackwellJennifer A PietenpolPublished in: American journal of respiratory and critical care medicine (2023)
Loss of functional p73 in murine airway epithelium results in the absence of MCCs and promotes COPD-like lung pathology. In smokers and patients with COPD, loss of p73 may contribute to MCC loss or dysfunction.