Virological suppression and clinical management in response to viremia in South African HIV treatment program: A multicenter cohort study.
Lucas E HermansSergio CarmonaMonique NijhuisHugo A TempelmanDouglas D RichmanMichelle A MoorhouseDiederick E GrobbeeWillem Daniel Francois VenterAnnemarie M J WensingPublished in: PLoS medicine (2020)
In this study, 90% virological suppression below the threshold of 1,000 copies/mL was observed in on-treatment analysis. However, this target was not met at the 50-copies/mL threshold or in intention-to-treat analysis. Clinical management in response to viremia was profoundly delayed, prolonging the duration of viremia and potential for transmission. Diagnostic tools to establish the cause of viremia are urgently needed to accelerate clinical decision-making.