Axl expression is increased in early stages of left ventricular remodeling in an animal model with pressure-overload.
Montserrat BatlleNadia CastilloAnna AlcarrazSebastian SarvariGemma SangüesaHelena CristóbalPablo García de FrutosMarta SitgesLluis MontEduard GuaschPublished in: PloS one (2019)
Axl expression pattern suggests a role in the early progression of LV remodeling in HF but not in the later systolic dysfunction. The higher levels of circulating AXL found in HF patients most probably shed from the heart.
Keyphrases
- left ventricular
- tyrosine kinase
- poor prognosis
- heart failure
- end stage renal disease
- newly diagnosed
- ejection fraction
- blood pressure
- prognostic factors
- binding protein
- acute heart failure
- oxidative stress
- hypertrophic cardiomyopathy
- long non coding rna
- patient reported outcomes
- cardiac resynchronization therapy
- mitral valve
- aortic valve
- left atrial
- transcatheter aortic valve replacement
- percutaneous coronary intervention