Exploring the role of non-coding RNAs in autophagy.
Soudeh Ghafouri-FardHamed ShooreiMahdi MohaqiqJamal MajidpoorMohammad Amin MoosaviMohammad TaheriPublished in: Autophagy (2021)
As a self-degradative mechanism, macroautophagy/autophagy has a role in the maintenance of energy homeostasis during critical periods in the development of cells. It also controls cellular damage through the eradication of damaged proteins and organelles. This process is accomplished by tens of ATG (autophagy-related) proteins. Recent studies have shown the involvement of non-coding RNAs in the regulation of autophagy. These transcripts mostly modulate the expression of ATG genes. Both long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) have been shown to modulate the autophagy mechanism. Levels of several lncRNAs and miRNAs are altered in this process. In the present review, we discuss the role of lncRNAs and miRNAs in the regulation of autophagy in diverse contexts such as cancer, deep vein thrombosis, spinal cord injury, diabetes and its complications, acute myocardial infarction, osteoarthritis, pre-eclampsia and epilepsy.Abbreviations: AMI: acute myocardial infarction; ATG: autophagy-related; lncRNA: long non-coding RNA; miRNA: microRNA.
Keyphrases
- long non coding rna
- cell death
- acute myocardial infarction
- endoplasmic reticulum stress
- poor prognosis
- oxidative stress
- signaling pathway
- induced apoptosis
- spinal cord injury
- cell cycle arrest
- type diabetes
- left ventricular
- heart failure
- spinal cord
- squamous cell carcinoma
- coronary artery disease
- network analysis
- insulin resistance
- dna methylation
- gene expression
- papillary thyroid
- pi k akt
- neuropathic pain
- long noncoding rna
- young adults
- atrial fibrillation
- lymph node metastasis