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THADA drives Golgi residency and upregulation of PD-L1 in cancer cells and provides promising target for immunotherapy.

Chushu LiHao ChiShouyan DengHuanbin WangHan YaoYungang WangDawei ChenXun GuoJing-Yuan FangFang HeJie Xu
Published in: Journal for immunotherapy of cancer (2022)
Our data reveal a crucial cellular process for PD-L1 maturation and maintenance in tumor cells, and highlight THADA as a promising target for overcoming PD-L1-dependent immune evasion.
Keyphrases
  • poor prognosis
  • electronic health record
  • genome wide
  • cell proliferation
  • big data
  • signaling pathway
  • single cell
  • endoplasmic reticulum
  • medical students
  • long non coding rna
  • data analysis