Exosomal lncRNA PVT1/VEGFA Axis Promotes Colon Cancer Metastasis and Stemness by Downregulation of Tumor Suppressor miR-152-3p.

Shiue-Wei Lai Ming-Yao Chen Oluwaseun Adebayo Bamodu Ming-Shou Hsieh Ting-Yi Huang Chi-Tai Yeh Wei-Hwa Lee Yih-Giun Cherng

Published in: Oxidative medicine and cellular longevity (2021)

Exosomal PVT1 promotes colon cancer metastasis through its association with EGFR and VEGFA expression. miR-152-3p targets both PVT1 and VEGFA, and this regulatory pathway can be explored for drug development and as a prognostic biomarker.

Keyphrases

small cell lung cancer
poor prognosis
stem cells
epidermal growth factor receptor
cell proliferation
transcription factor
epithelial mesenchymal transition
long non coding rna
signaling pathway
binding protein