Epigenetic aging and PTSD outcomes in the immediate aftermath of trauma.

Anthony S ZannasSarah D LinnstaedtXinming AnJennifer S StevensNathaniel G HarnettAlyssa R RoecknerKatelyn I OliverDavid R RubinowElisabeth B BinderKarestan C KoenenKerry J ResslerSamuel A McLean

Published in: Psychological medicine (2023)

Our findings shed new light on the relation between biological aging and trauma-related phenotypes, suggesting that GrimAge measured at the time of trauma predicts PTSD trajectories and is associated with relevant brain alterations. Furthering these findings has the potential to enhance early prevention and treatment of posttraumatic psychiatric sequelae.

Keyphrases

trauma patients
posttraumatic stress disorder
dna methylation
social support
mental health
gene expression
depressive symptoms
resting state
white matter
metabolic syndrome
functional connectivity
replacement therapy
weight loss
drug induced