Effect of Mimic Hypoxia on the Proliferation and Expression of miR-27a, miR-9, miR-370 and their Target Genes in MOLT-4 and KG1a Cell Lines.

Behnam Emaogolizadeh Gurd TapehAli MohammadiMohammad Reza AlivandSaeed Solali

Published in: Asian Pacific journal of cancer prevention : APJCP (2021)

Treatment with CoCl2 has an inhibitory effect on the proliferation of MOLT-4 and KG1 cell lines independent from real hypoxia. Additionally, mimic hypoxia has a substantial effect on the expression of genes and miRNAs involved in drug resistance. Finally, we are still far away to discover the exact functional mechanisms of hypoxia on drug resistance but these evaluations can provide new perspectives into this field for the upcoming studies.

Keyphrases

long non coding rna
poor prognosis
cell proliferation
endothelial cells
long noncoding rna
signaling pathway
genome wide
binding protein
bioinformatics analysis
dna methylation
density functional theory