Oxyresveratrol Improves Cognitive Impairments and Episodic-like Memory through Modulating Neuroinflammation and PI3K-Akt Signaling Pathway in LPS-Induced Mice.
Guangling YinChunxing PanHong LiuChangzhi DongXia ChangWei ZhouShanshan WangZhiyun DuPublished in: Molecules (Basel, Switzerland) (2024)
Oxyresveratrol is one of the active ingredients derived from mulberry branch with strong anti-inflammatory bioactivity. In this research, we want to explore if oxyresveratrol can improve cognitive impairments and episodic-like memory and its mechanism. In LPS-induced BV-2 cells, 25 μM OXY can significantly inhibit the expression of NO and alter the M1/M2 polarization by regulating M1/M2 phenotype makers. In vivo, OXY (50, 100 mg/kg) significantly reversed cognitive impairments and alleviated neuronal injuries caused by neuroinflammation. According to network pharmacology analysis, OXY alleviated neuroinflammation via the PI3K-Akt pathway. In general, the research revealed that OXY can improve cognitive impairments and episodic-like memory through alleviating LPS-induced neuroinflammation and regulating the PI3K-Akt signaling pathway.
Keyphrases
- lps induced
- signaling pathway
- pi k akt
- inflammatory response
- cell cycle arrest
- induced apoptosis
- working memory
- cell proliferation
- epithelial mesenchymal transition
- lipopolysaccharide induced
- anti inflammatory
- poor prognosis
- type diabetes
- single cell
- brain injury
- binding protein
- adipose tissue
- long non coding rna
- skeletal muscle