Relation of placental alkaline phosphatase expression in human term placenta with maternal and offspring fat mass.

Birgit HirschmuglSarah CrozierNina MatthewsEva KitzingerIngeborg KlymiukHazel M InskipNicholas C HarveyCyrus CooperColin P SibleyJocelyn GlazierChristian WadsackKeith M GodfreyGernot DesoyeRohan M Lewis

Published in: International journal of obesity (2005) (2018)

Our findings suggest relationships between placental alkaline phosphatase and both maternal and childhood adiposity. The inverse relationship between placental alkaline phosphatase gene expression and childhood %fat mass suggests that placental alkaline phosphatase may help to protect the foetus from the adverse effects of maternal obesity.

Keyphrases

birth weight
gene expression
weight gain
insulin resistance
adipose tissue
pregnancy outcomes
gestational age
endothelial cells
poor prognosis
type diabetes
high fat diet
dna methylation
preterm infants
early life
body mass index
binding protein
childhood cancer