Genome-wide CRISPR screens for the identification of therapeutic targets for cancer treatment.

Vivian Weiwen XueSze Chuen Cesar WongWilliam Chi Shing Cho

Published in: Expert opinion on therapeutic targets (2020)

The application of CRISPR-based therapeutic target screening is broadly used in cancer drug development. Its application in cancer immunotherapy and precision oncology is blooming. Nevertheless, more effective methods of Cas protein delivery and the development of more accurate and efficient genome-editing tools are needed.

Keyphrases

genome editing
genome wide
crispr cas
dna methylation
papillary thyroid
palliative care
squamous cell
copy number
protein protein
amino acid
squamous cell carcinoma
lymph node metastasis
binding protein
young adults
bioinformatics analysis
mass spectrometry