Uric acid increases cellular and humoral alloimmunity in primary human peripheral blood mononuclear cells.

Theodoros EleftheriadisGeorgios PissasMaria SounidakiGeorgia AntoniadiNikolaos AntoniadisVassilios LiakopoulosIoannis Stefanidis

Published in: Nephrology (Carlton, Vic.) (2018)

Uric acid increases both cellular and humoral alloimmunity in human PBMC. These results offer a possible pathogenetic mechanism for the observed relation between hyperuricaemia and worse kidney allograft survival.

Keyphrases

uric acid
metabolic syndrome
endothelial cells
immune response
induced pluripotent stem cells
pluripotent stem cells
kidney transplantation
free survival