Dietary intervention, but not losartan, completely reverses non-alcoholic steatohepatitis in obese and insulin resistant mice.
Jef VerbeekPieter SpincemailleIlse VanhorebeekGreet Van den BergheIngrid Vander ElstPetra WindmoldersJos van PeltSchalk van der MerwePierre BedossaFrederik NevensBruno CammueKarin ThevissenDavid CassimanPublished in: Lipids in health and disease (2017)
Dietary intervention, and not losartan, completely restores the metabolic phenotype in a representative mouse model with pre-existent NASH, obesity, insulin resistance and hypercholesterolemia.
Keyphrases
- insulin resistance
- high fat diet induced
- type diabetes
- metabolic syndrome
- adipose tissue
- randomized controlled trial
- mouse model
- weight loss
- angiotensin ii
- high fat diet
- glycemic control
- skeletal muscle
- polycystic ovary syndrome
- bariatric surgery
- liver injury
- cardiovascular disease
- weight gain
- obese patients
- wild type
- low density lipoprotein