Expression of HIF1α in intestinal epithelium restricts arthritis inflammation by inhibiting RIPK3-induced cell death machinery.
Pang LyuJinming WenWenshuo ZhangNing LiuIris StolzerAndreas GießlYewei JiaDaniele MauroFulin ZhangFrancesco CicciaDidier SoulatClaudia GüntherLarissa Valor-MéndezAline BozecPublished in: Annals of the rheumatic diseases (2024)
Our results identify IEC necroptosis as a critical link between the gut and the development of arthritis.