Genetic variants of LEAP2 are associated with anthropometric traits and circulating insulin-like growth factor-1 concentration: A UK Biobank study.

María F Andreoli Mélissa GentreauGull RukhMario PerelloHelgi B Schiöth

Published in: Diabetes, obesity & metabolism (2024)

These findings reveal sex-specific associations between key LEAP2 gene variants and several obesity traits, while also indicating a strong independent association of LEAP2 variants with serum IGF-1 concentration.

Keyphrases

genome wide
copy number
dna methylation
metabolic syndrome
insulin resistance
type diabetes
weight loss
growth hormone
weight gain
cross sectional
single cell
high fat diet induced
adipose tissue
body mass index
signaling pathway
transcription factor