Effects of adolescent intermittent ethanol exposure on cortical perineuronal net and parvalbumin expression in adulthood mediate behavioral inflexibility.

Emily D K SullivanCarol A DannenhofferElizabeth B SutherlandElena M VidrascuAlexander Gómez-ACharlotte A Boettiger Donita L Robinson

Published in: Alcohol, clinical & experimental research (2024)

This study reveals a significant link between AIE exposure, neural alterations, and diminished behavioral flexibility in rats, and highlights a potential novel mechanism comprising changes in PV and PNN measures within the AIC. Future studies should explore the impact of PNN degradation within the AIC on behavioral flexibility.

Keyphrases

poor prognosis
young adults
mental health
current status
binding protein
fluorescent probe
long non coding rna
human health
early life