Integrated Multi-Cohort Analysis of the Parkinson's Disease Gut Metagenome.

Joseph C Boktor Gil Sharon Leonard VerhagenDeborah A HallPhillip A EngenZoe ZreloffDaniel J HakimJohn W Bostick James A OuseyDanielle LangeGregory HumphreyGail L Ackermann Martha Carlin Rob Knight Ali Keshavarzian Sarkis K Mazmanian

Published in: Movement disorders : official journal of the Movement Disorder Society (2023)

A metagenomic meta-analysis of PD shows consistent and novel alterations in functional metabolic potential and microbial gene abundance across four independent studies from three continents. These data reveal that stereotypic changes in the functional potential of the gut microbiome are a consistent feature of PD, highlighting potential diagnostic and therapeutic avenues for future research. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyphrases

genome wide
human health
machine learning
systematic review
risk assessment
randomized controlled trial
electronic health record
deep learning
big data
copy number
transcription factor
dna methylation
artificial intelligence
case control
wastewater treatment