The association between apolipoprotein E and gallstone disease: an updated meta-analysis.

Lizhuo LiXin QiaoXia WangDi LiuQingmu XueLu HanFei DaiGuomin MaZhipeng YangTao ZhangShuo YangShikang CaiMingyue GaoJingyun Yang

Published in: BMC medical genetics (2019)

Our meta-analysis found insufficient evidence for the effect of APOE E4 on GSD risk. Future studies with large sample sizes that control for important confounding/risk factors are needed to validate our findings and to explore other genetic loci that might affect GSD risk.

Keyphrases

systematic review
case control
risk factors
meta analyses
genome wide
cognitive decline
randomized controlled trial
high fat diet
adipose tissue
insulin resistance
skeletal muscle
genome wide association study
mild cognitive impairment