Role of ZNF143 and Its Association with Gene Expression Patterns, Noncoding Mutations, and the Immune System in Human Breast Cancer.
Salma SaddeekRehab F AlMassabiMohammad MobashirPublished in: Life (Basel, Switzerland) (2022)
The function of noncoding sequence variations at ZNF143 binding sites in breast cancer cells is currently not well understood. Distal elements and promoters, also known as cis-regulatory elements, control the expression of genes. They may be identified by functional genomic techniques and sequence conservation, and they frequently show cell- and tissue-type specificity. The creation, destruction, or modulation of TF binding and function may be influenced by genetic modifications at TF binding sites that affect the binding affinity. Therefore, noncoding mutations that affect the ZNF143 binding site may be able to alter the expression of some genes in breast cancer. In order to understand the relationship among ZNF143, gene expression patterns, and noncoding mutations, we adopted an integrative strategy in this study and paid close attention to putative immunological signaling pathways. The immune system-related pathways ErbB, HIF1a, NF-kB, FoxO, JAK-STAT, Wnt, Notch, cell cycle, PI3K-AKT, RAP1, calcium signaling, cell junctions and adhesion, actin cytoskeleton regulation, and cancer pathways are among those that may be significant, according to the overall analysis.
Keyphrases
- pi k akt
- cell proliferation
- signaling pathway
- cell cycle
- gene expression
- poor prognosis
- genome wide
- cell cycle arrest
- single cell
- endothelial cells
- dna methylation
- binding protein
- breast cancer cells
- cell therapy
- stem cells
- transcription factor
- papillary thyroid
- minimally invasive
- induced apoptosis
- genome wide identification
- cell migration
- bioinformatics analysis
- epithelial mesenchymal transition
- working memory
- dna binding
- single molecule
- tyrosine kinase
- escherichia coli
- cystic fibrosis
- nuclear factor
- breast cancer risk
- lps induced
- network analysis