Double bonds of unsaturated fatty acids differentially regulate mitochondrial cardiolipin remodeling.
Hsiu-Chi TingLi-Tzu ChenJo-Yu ChenYi-Li HuangRui-Cheng XinJui-Fen ChanYuan-Hao Howard HsuPublished in: Lipids in health and disease (2019)
The process of fatty acid incorporation to CL was regulated by the fatty acid desaturation and transportation into mitochondria in macrophage. The double bonds of fatty acids significantly affect the incorporation process and preference. Intact OA(18:1) was incorporated to CL; LA(18:2) and ALA(18:3) were desaturated and elongated to long chain fatty acid before the incorporation; GLA(18:3) and SDA(18:4) were unfavorable for the CL incorporation.