Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activities.
Juha MehtonenSusanna TeppoMari LahnalampiAleksi KokkoRiina KaukonenLaura OksaMaria Bouvy-LiivrandAlena MalyukovaArtturi MäkinenSaara LaukkanenPetri I MäkinenSamuli RouniojaPekka RuusuvuoriOlle SangfeltRiikka LundTapio LönnbergOlli LohiMerja HeinäniemiPublished in: Genome medicine (2020)
Our data provide a detailed picture of the transcription factor activities characterizing both normal B-lineage differentiation and those acquired in leukemic bone marrow and provide a rational basis for new treatment strategies targeting the immune microenvironment and the active regulatory network in leukemia.
Keyphrases
- transcription factor
- single cell
- bone marrow
- acute myeloid leukemia
- rna seq
- dna binding
- mesenchymal stem cells
- high throughput
- acute lymphoblastic leukemia
- electronic health record
- genome wide identification
- cancer therapy
- big data
- cell therapy
- emergency department
- dna methylation
- artificial intelligence
- drug induced
- drug delivery