Abrocitinib Attenuates Microglia-Mediated Neuroinflammation after Traumatic Brain Injury via Inhibiting the JAK1/STAT1/NF-κB Pathway.
Tuo LiLei LiRuilong PengHongying HaoHejun ZhangYalong GaoCong WangFanjian LiXilei LiuFanglian ChenShu ZhangJianning ZhangPublished in: Cells (2022)
Collectively, abrocitinib treatment after TBI is accompanied by improvements in neurological function consistent with radiological, histopathological, and biochemical changes. Therefore, abrocitinib can indeed reduce excessive neuroinflammation by restraining the JAK1/STAT1/NF-κB pathway.
Keyphrases
- lps induced
- inflammatory response
- signaling pathway
- traumatic brain injury
- lipopolysaccharide induced
- cerebral ischemia
- pi k akt
- nuclear factor
- oxidative stress
- cognitive impairment
- toll like receptor
- weight gain
- severe traumatic brain injury
- physical activity
- blood brain barrier
- weight loss
- mild traumatic brain injury