GATA factor transcriptional activity: Insights from genome-wide binding profiles.
Oriana RomanoAnnarita MiccioPublished in: IUBMB life (2019)
The members of the GATA family of transcription factors have homologous zinc fingers and bind to similar sequence motifs. Recent advances in genome-wide technologies and the integration of bioinformatics data have led to a better understanding of how GATA factors regulate gene expression; GATA-factor-induced transcriptional and epigenetic changes have now been analyzed at unprecedented levels of detail. Here, we review the results of genome-wide studies of GATA factor occupancy in human and murine cell lines and primary cells (as determined by chromatin immunoprecipitation sequencing), and then discuss the molecular mechanisms underlying the mediation of transcriptional and epigenetic regulation by GATA factors.
Keyphrases
- transcription factor
- genome wide
- dna methylation
- gene expression
- dna binding
- endothelial cells
- copy number
- induced apoptosis
- genome wide identification
- high glucose
- single cell
- dna damage
- depressive symptoms
- cell cycle arrest
- binding protein
- cell death
- induced pluripotent stem cells
- dna repair
- case control
- pluripotent stem cells
- pi k akt
- oxide nanoparticles
- drug induced
- heat shock protein