DNA methylation down-regulates integrin β4 expression in asthmatic airway epithelial cells.

Mengping WuYu YangLin YuanMing YangLeyuan WangXizi DuLing QinShuangyan WuYang XiangXiangping QuHuijun LiuXiaoqun QinChi Liu

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2020)

This study confirmed that DNA methylation regulates the decreased expression of ITGB4 in the airway epithelial cells of asthma patients. These results supply some useful insights to the mechanism of the decreased ITGB4 in asthmatic airway epithelial and provide possible targets for early prediction and screening of asthma.

Keyphrases

dna methylation
lung function
poor prognosis
chronic obstructive pulmonary disease
end stage renal disease
gene expression
genome wide
newly diagnosed
ejection fraction
chronic kidney disease
cystic fibrosis
peritoneal dialysis
allergic rhinitis
binding protein
long non coding rna