Treg-driven tumour control by PI3Kδ inhibition limits myeloid-derived suppressor cell expansion.
Sarah Nicol LauderKathryn SmartValentina M T BartAna PiresJake ScottStefan MilutinovicAndrew GodkinBart VanhaesebroeckAwen GallimorePublished in: British journal of cancer (2022)
Our data suggest that MDSCs are not inhibited directly by PI-3065 treatment but that their reduced recruitment and immunosuppression within the tumour microenvironment is an indirect consequence of PI3Kδ-inhibition-driven tumour control. This indicates that PI3Kδ inhibition drives tumour immunity by breaking down multiple immunosuppressive pathways through both direct mechanisms (on Treg) and indirect mechanisms, secondary to tumour control (on MDSCs).